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Benefits of albumin in severe sepsis
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Significant haemodynamic advantages compared to crystalloids
Fluid management is one of the main factors in the successful resuscitation and stabilisation of septic patients. Adequate oncotic pressure and intravascular volume provided by albumin have shown advantages in severe sepsis.
In severe sepsis, the administration of albumin has been shown to
Combined with crystalloids versus crystalloids alone
Significantly more septic patients reached the MAP target
(> 65 mmHg) within
6 hours (p=0.04)
Higher average blood pressure (p = 0.03)
In septic patients, in the first 7 days of treatment with albumin
Lower heart rate
(p = 0.002)
In septic patients, in the first 7 days of treatment with albumin
Lower cumulative net fluid balance (p = 0.004)
In septic patients, in the first 7 days of treatment with albumin
Significantly lower 90-day mortality in septic shock1
In the same study, univariate and multivariate post hoc analyses of 1,121 patients with septic shock showed significantly lower 90-day mortality in the albumin group compared to the crystalloid group (p = 0.03).
Reference
Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M, Fanizza C, Caspani L, Faenza S, Grasselli G, Iapichino G, Antonelli M, Parrini V, Fiore G, Latini R, Gattinoni L; ALBIOS Study Investigators. Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med. 2014 Apr 10;370(15):1412-21. doi: 10.1056/NEJMoa1305727. Epub 2014 Mar 18. PMID: 24635772. [PubMed~]
