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Accurate prevention and fast control of life-threatening bleeding
octaplex®
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octaplex® is a plasma-derived four-factor prothrombin complex concentrate (4F-PCC). 1
It contains coagulation factors II, VII, IX and X and also the naturally occurring anticoagulants protein C and protein S.1
25-fold higher PCC concentration (based on FIX) than FFP, delivered in a small volume.1
Blood type identification is not required.1
Room temperature storage.1
high level of pathogen safety via specialised production steps1,2
octaplex® is indicated for
Acquired deficiency of prothrombin factors1
Treatment and peri-operative prophylaxis of bleeding in patients with acquired prothrombin complex factor deficiency, such as from VKA treatment or overdose, when rapid correction is needed.
Congenital deficiency of factor II or factor X1
Treatment and peri-operative prophylaxis of bleeding in patients with congenital deficiency of the vitamin K-dependent coagulation factors II and X when purified specific coagulation factor product is not available.
octaplex® quickly reverts vitamin K antagonists (VKA) associated-bleeding1,2
And unlike FFP, is ready to be used:
Rapidly reverses INR
within 10 minutes3
Reduces the need
for RBC transfusions4
In 95% of cases, a single dose is sufficient to reverse INR5
This percentage increased to 100% in patients with significantly elevated INR and a high risk of haemorrhage.
Is well tolerated and shows a low thrombogenic profile6
Quick reconstitution and easy administration¹
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References
octaplex® Summary of Product Characteristics
Biesert L et al. Viral safety of a prothrombin complex concentrate (octaplex®): Combination of solvent/detergent (SD) treatment with nanofiltration. J Thromb Haemost 2005; 3, Supplement 1: P0655
Lubetsky A, Hoffman R, Zimlichman R, Eldor A, Zvi J, Kostenko V, Brenner B. Efficacy and safety of a prothrombin complex concentrate (Octaplex) for rapid reversal of oral anticoagulation. Thromb Res. 2004;113(6):371-8. doi: 10.1016/j.thromres.2004.04.004. PMID: 15226091. [PubMed]
Hickey M, Gatien M, Taljaard M, Aujnarain A, Giulivi A, Perry JJ. Outcomes of urgent warfarin reversal with frozen plasma versus prothrombin complex concentrate in the emergency department. Circulation. 2013 Jul 23;128(4):360-4. doi: 10.1161/CIRCULATIONAHA.113.001875. Epub 2013 Jun 14. PMID: 23770745. [PubMed]
Carvalho MC, Rodrigues AG, Conceição LM, Galvão ML, Ribeiro LC. Prothrombin complex concentrate (Octaplex): a Portuguese experience in 1152 patients. Blood Coagul Fibrinolysis. 2012 Apr;23(3):222-8. doi: 10.1097/MBC.0b013e328351250f. Erratum in: Blood Coagul Fibrinolysis. 2013 Mar;24(2):220. PMID: 22450543. [PubMed]
Desmettre T, Dubart AE, Capellier G, Fanara B, Puyraveau M, Kepka S, Coquart J, Sheppard F, Tazarourte K. Emergency reversal of anticoagulation: the real use of prothrombin complex concentrates: a prospective multicenter two year French study from 2006 to 2008. Thromb Res. 2012 Sep;130(3):e178-83. doi: 10.1016/j.thromres.2012.05.029. Epub 2012 Jun 21. PMID: 22726885. [PubMed]
